| Obesity and low levels of physical activity are important risk factors for glycolipid metabolism disorder.The traditional view is that low and medium intensity continuous exercise can effectively reduce the body fat content and improve the level o f glucose and lipid.Compared with the normal weight group,the effect of exercise on glucose and lipid metabolism is more significant,but there are also some problems such as longer exercise time,monotonous rhythm and so on.In contrast,the high intensity intermittent training exercise time is short,and the intensity of exercise is very large,which seems to be an effective method to reduce body fat.From the current research results,high-intensity intermittent training fat reduction effect has been confirmed,and improve blood glucose and lipid obesity effect is confirmed,but the mechanism of movement to regulate glucose and lipid metabolism is not clear.It is found that FGF21 is an endocrine factor involved in energy metabolism,and FGF21 has the effects of lowering blood glucose and improving insulin sensitivity.In the aspect of lipid metabolism,FGF21 can improve lipid metabolism by reducing lipid synthesis,decomposition,improve lipid metabolism disorders.However,there is little research on the effects of long-term exercise on FGF21.In this study,we observed the effect of FGF21 on the prevention of obesity and metabolic diseases in obese people by observing the effect of different intensity training on the expression of FGF21 in obese people,and provided the theoretical basis for the improvement of glucose and lipid metabolism in the obese population.Objective: To compare the effects of 12-week high intensity interval training and moderate intensity continuous training on glucose and lipid metabolism in obese young women,and to explore the role of FGF21 in improving glucose and lipid metabolism.Methods: 54 obese young women were randomly divided into 4 groups: HIIT、 SIT、MICT and CON.The exercise group was followed by 12 weeks of exercise intervention,the control group did not exercise.During the intervention,the average dietary calorie intake and the amount of physical activity were consistent with those before intervention.The body fat percentage,body fat mass,body lean body weight,maximal oxygen uptake(V?O2max),blood and other indexes were measured before and after 12 weeks of intervention.The exercise group used the power car for treadmill training.The SIT group used to treadmill exercise for 9 seconds,and then rest 6 seconds,the first 4 weeks to adapt to the initial load of 1kg,and the next 8 weeks need to increase the exercise load gradually,each time need to complete 80 groups.During the first 4 weeks the HIIT group were treated with 90% VO2 max intensity,exercise for 4 min and intermittent for 3 min,then repeated until the completion of 200 kJ mechanical work.At the same time the MICT group was treated with 60% VO2 max strength continuous treadmill until the completion of 200 KJ mechanical work.In the last 8 weeks of training,HIIT and MICT group were overcome 300 KJ mechanical work respectively.Results:(1)Before and after 12 weeks of intervention,the changes of body fat and lean body weight in each group.The body fat of the exercise group was lower than that before the intervention,and the statistical difference was significant(HIIT: 67.3±6.1 vs 64.0±6.0 kg;SIT: 66.7±6.4 vs 64.9±6.2 kg: MICT: 68.5±8.0 vs 65.1±7.7 kg,p<0.01);There was no significant difference among the three exercise groups.There was no significant difference in CON group before and after intervention(p>0.05).There was no significant difference in lean body weight among the four groups before and after 12 weeks of intervention.(2)Before and after 12 weeks of intervention,the changes of blood lipids and blood sugar in each group.Compare to themselves,there were no significant differences in triglyceride and cholesterol levels before and after 12 weeks of intervention(p>0.05).The HDL content of exercise group was higher than that before intervention,and the difference was significant(HIIT: 1.35±0.22 vs 1.56±0.15 mmol/L;SIT: 1.30±0.11 vs 1.73±0.14 mmol/L;MICT: 1.44±0.10 vs 1.76±0.10 mmol/L,p<0.01);There was no difference among the three exercise groups.There was no significant difference in CON group before and after intervention(p>0.05).The LDL content of the exercise groups was higher than that before the intervention,and the difference was statistically significant(HIIT: 1.85±0.29 vs 1.61±0.15mmol/L;SIT: 1.91±0.18 vs 1.43±0.17 mmol/L;MICT: 1.73±0.15 vs 1.42±0.09 mmol/L,p<0.01);There was no difference among the three exercise groups.There was no significant difference in CON group before and after intervention(p>0.05).The blood glucose of the MICT group decreased after 12 weeks of exercise intervention and had a statistically significant difference(5.57±0.11 vs 5.33±0.20 mmol/L,p<0.05),The blood glucose of HIIT and SIT did not change after 12 weeks of exercise intervention(HIIT: 5.54±0.30 vs 5.62±0.11mmol/L;SIT: 5.53±0.44 vs 5.63±0.10 mmol/L,p>0.05).HIIT compared with SIT group,no group difference(p>0.05),There was a significant difference between the HIT group and the MICT group(p<0.05),SIT compared with MICT group,the difference was obvious(p<0.05).There was no significant difference in CON group before and after intervention(p>0.05).(3)INS 、HOMA-IS 、 GH、 FGF21 were observed before and after 12 weeks of interventionThe level of INS in exercise group was lower than that before intervention,and the difference was significant(HIIT: 2.59±0.73 vs 1.95±0.69 μIU/ml;SIT: 2.02±0.62 vs 1.39±0.70 μIU/ml;MICT: 1.93±0.41 vs 1.48±0.44 μIU/ml,p<0.01).HIIT compared with SIT group,the difference was obvious(p<0.05),There was a significant difference between the HIT group and the MICT group(p<0.05),SIT group compared with MICT group,no group difference(p>0.05).There was no significant difference in CON group before and after intervention(p>0.05).The level of HOMA-IS in exercise group was lower than that before intervention,and the difference was significant(HIIT: 0.08±0.03 vs 0.10±0.03,p<0.05;SIT: 0.10±0.02 vs 0.15±0.06;MICT: 0.10±0.02 vs 0.15±0.05,p<0.01).HIIT group compared with SIT group,the difference was significant(p<0.01),HIIT group compared with MICT group,there were differences between groups(p<0.05),SIT group compared with MICT group,no group difference(p>0.05).There was no significant difference in CON group before and after intervention(p>0.05).There was no significant difference in GH levels among the four groups before and after 12 weeks(p>0.05).The level of FGF21 in exercise group was lower than that before intervention,and the difference was significant(HIIT: 0.91±0.23 vs 0.74±0.27 ng/ml;SIT: 1.02±0.23 vs 0.71±0.19 ng/ml;MICT: 0.92±0.18 vs 0.71±0.18 ng/ml,p<0.01);But there was no difference among the three exercise groups.There was no significant difference in CON group before and after intervention(p>0.05).Conclusions:(1)High intensity interval training and moderate intensity continuous training can improve the lipid metabolism in young obese people,one of the mechanisms may play a role by reducing the level of blood FGF21;(2)High intensity interval training to reduce serum FGF21 effect is the same as moderate intensity continuous training. |
