The Influence Of R-hLH Added On The Trigger Day And Afterwards On The Outcome Of IVF Pregnancy

Objective: The aim of the present study is to investigate the low-dose LH(LH < 1.2mIU/mL)of trigger day in IVF/ICSI-ET fertility patients on the trigger day and/or oviposition day and transplant day to add exogenous luteinizing hormone effects of pregnancy outcomes.Materials and Methods:This is a randomized clinical trial study that was performed from May 2016 to December 2017 on 324 infertile patients for in vitro fertilization/intracytoplasmic sperm injection-embryo transfer(IVF/ICSI)and fresh embryo transplantation in general hospital of Ningxia University.The women were randomly divided into two treatment groups.Patients with HCG serum LH less than 1.2 U/L were randomly assigned to group A(162 cases)and group B(162 cases)using a randomized control principle.Then,we assessed the outcomes such as chemical and clinical pregnancy rate,live birth and abortion rate.Results :1.The implantation rate,pregnancy rate,abortion rate and live birth rate difference is not obviously statistical significant between the group A(intervention group)and group B(control group)(P > 0.05).2.Age groups:In aged between 26 to 30 years old,implantation rate and clinical pregnancy rate are significantly higher than that of other age groups,but there was no statistically significant difference(P > 0.05).In Aged group(36-42 years old),implantation and pregnancy rate is not obviously statistical significant between the group A(intervention group)and group B(control group)(P > 0.05).3.Luteal support in group A andgroup B clinical pregnancy cases:The dosage of E2 in group A was significantly lower than that in group B,and the difference was statistically significant(P < 0.05),and the dosage of progesterone was lower than that in group B,the difference was not significant(P>0.05).4.LH level groups:When LH leveled between 0.51 to 1.0 mIU/m,clinical pregnancy rate is not obviously statistical significant between the group A(intervention group)and group B(control group)(P > 0.05).When LH leveled between0.51 to 1.0 m IU/mL,implantation rate is higher in A group than in B group,but with no statistical significance(P > 0.05).Conclusion: 1.The elderly patients may improve the implantation and pregnancy rate by exogenous routinizing hormone.2.Compare exogenous routinizing group on the conurbation day and the monocyte retrieval day and the non-addition group,there was no significant difference between the two groups.3.Addition of exogenous routinizing hormone can reduce Lutheran support dose.4.The clinical outcome of exogenous luteinizing hormone at different LH levels on the trigger day is different,suggesting that LH may have a certain optimum concentration range,and adding r-hLH may improve the outcome of pregnancy.