Study On The Correlation Between The Changes Of Procalcitonin And The Infection Of Stroke In Patients With Acute Ischemic Stroke

Background:Cerebrovascular disease is one of death and disability in china,stroke costs about 10 percent of all diseases each year,the most effective treatment is thrombolytic therapy.sroke-associated infection is an independent risk factor of poor clinical outcomes.Early predictors for the development of stroke-associated infection may identify patients at high risk and reduce post-stroke infection and mortality.Reduce the heavy burden on society and families.Methods:In 40 prospectively enrolled acute stroke patients underwent intravenous thrombolysis we assessed time point and type of post-stroke infections(i.e.pneumonia,urinary tract infection other infection).Blood samples were collected on admission,and 24 hours after admission,and 48 hours after admission white blood cells,C-reactive protein and procalcitonin.To determine the magnitude of association with the development of infections,odds ratios(OR)were calcu-lated for each prognostic blood marker.The discriminatory ability of different predictors was assessed,by calculating area under the receiver operating characteristic curves.Results:Of 40 patients,8(20%)developed an infection after onset of stroke.White blood cells,C-reactive protein and procalcitonin were all independent predictors of any infection,pneumonia and urinary tract infection developed at least 24 hours after measurements.Conclusion:PCT combined with blood routine leukocyte and CPR test had a clear help for the evaluation of SAI.Screening of PCT blood routine white blood cells and CPR 24 hours after admission and 48 hours after admission can help to distinguish the possibility of a patient with a SAI.The diagnosis of patients with high risk infection with thrombolysis can be of great help.