| Objective: The correlation between subclinical thyroid dysfunction and the risk of cardiovascular outcomes are still conflicting.This Meta-analysis was used to evaluate the association between subclinical thyroid dysfunction and the risk of cardiovascular outcomes.Methods: PubMed,EMbase,The Cochrane Library,Web of Science,and China Biology Medicine(CBM)databases were searched for target studies from inception to December,2017.According to the inclusion and exclusion criteria,the literature was screened,data extracted and quality evaluation.Then,meta-analysis was performed by using Stata 12.0 software.Results: Finally,16 studies with 71,808 participants were included in our meta-analysis.The results showed that the RR and 95%CI of subclinical hypothyroidism and coronary heart disease(CHD),total mortality,cardiovascular mortality,heart failure and atrial fibrillation were respectively: RR=1.17;95% CI,0.91-1.52、 RR=1.02;95% CI,0.93-1.13、 RR= 1.06;95% CI,0.77-1.45、 RR=1.17;95% CI,0.87-1.57、 RR=1.05;95% CI,0.91-1.21;Subgroup analysis showed that the average age <65 years,the RR and 95%CI of subclinical hypothyroidism and CHD was1.54(95% CI,1.00-2.39),and similar results were not found in other age groups.The RR and 95%CI of subclinical hyperthyroidism and CHD,total mortality,cardiovascular mortality,heart failure and atrial fibrillation were respectively: RR =1.20;95% CI,1.02-1.42 、 RR =1.27;95%CI,1.07-1.51、RR=1.12;95% CI,0.84-1.50、 RR=1.54;95%CI,0.87–2.71、RR=1.42;95% CI,0.69–2.92.Conclusions: subclinical hyperthyroidism may increase the risk of CHD and total mortality.Although its limitations,we believe that our findings could still provide useful information for stakeholders. |
