The Study On The Relationship Between Left Ventricular Hypertrophy And Prolactin In Postmenopausal Hypertensive Women

Obejective As women enter menopause,the levels of sexual hormones in women changes significantly.At the same time,the prevalence of hypertension is significantly higher than that before menopause,and the incidence and extent of target organ damage in hypertension are also higher.This study explored the relationship between prolactin(PRL)level and left ventricular hypertrophy(LVH)in postmenopausal women with hypertension.Methods A total of 128 menopausal women with hypertension were divided into hypertension with LVH group(n=63,group 1)and hypertension without LVH group(n=65,group 2).Selected postmenopausal women without hypertension matched the age,menopausal time with group 1 and group 2 as a control group(n=57,group 3).Blood biochemistry,sexual hormones,including PRL were measured in 3 groups.At the same time,echocardiography including left atrial diameter(LAD),left ventricular end diastolic diameter(LVEDD),interventricular septal thickness(IVST),left ventricular posterior wall thickness(LVPWT),left ventricular ejection fraction(LVEF),and early diastolic mitral flow velocity(E)and systolic mitral flow velocity(A)ratio(E /A)were measured.central artery blood pressure and cervical-femoral pulse wave velocity(cf-PWV)were measured.A statistical analysis of each parameter was performed to compare the differences in these parameters among the three groups.Results 1.Comparison of parameters among the three groups,(1)Basic index,there was no significant difference in age and menopausal time among the three groups(P>0.05)and the body mass index(BMI)in the hypertension with LVH group was significantly higher than those hypertension without LVH group and control group(25.08±3.31 kg/m2 vs 23.81±3.05 kg/m2 vs22.59±2.51 kg/m2 P<0.05).(2)Metabolic Indexes,there was no significant difference in glucose(Glu),triglyceride(TG),low density lipoprotein-cholesterol(LDL-C),high density lipoprotein-cholesterol(HDL-C),total cholesterol(TC)and blood urea nitrogen(BUN),uric acid(UA)(P>0.05)within these groups.(3)Sexual hormones,there was no significant difference in estradiol(E2)testosterone(T)progesterone(P)among the three groups(P>0.05),and the PRL in the hypertension with LVH group was significantly lower(9.64±4.22 ng/ml vs 11.89±5.86 ng/ml vs 15.55±5.74 ng/ml P<0.05)than those of without LVH group and control group.(4)Cardiac structure and function index,some cardiac structure indexes of hypertension with LVH group compared with hypertension without LVH group and cntrol group were significantly higher in LAD(35.64±3.33 mm vs 31.57±3.34 mm vs 30.26±2.77 mm P<0.05),IVST(1.09±0.19 cm vs 0.80±0.09 cm vs 0.77±0.10 cm P <0.05),LVPWT(1.09±0.15 cm vs 0.82±0.09 cm vs 0.81±0.08 cm P<0.05),and LVEDD(4.54±0.39 cm vs 4.24±0.36 cm vs 4.10±0.4 cm P<0.05).E/A(0.74±0.12 vs 0.86±0.22 vs 0.95±0.20 P <0.05).LVEF(64.25±4.16 % vs 70.32±4.57 % vs70.58±3.81 %,P<0.05)in hypertension with LVH group and hypertension without LVH group were significantly lower than that of control group(5)Vascular function index,cf-PWV in hypertension with LVH group were significantly higher than that of hypertension without LVH group and control group(8.65±2.36 m/s vs 7.31±2.12 m/s vs 6.03±1.33 m/s P<0.05).2.Multiple linear regression of PRL and cardiac structure and cardiac function shows IVST(γ=-0.325,P=0.013),LVPWT(γ=-0.296,P = 0.016),LVEF(γ= 0.241,P = 0.041).It has shown that the degree of decline in PRL was positively correlated with LVH in menopausal hypertensive women.Conclusion After menopause,the degree of decline in PRL is a risk factor for menopausal hypertensive women with LVH.