Quantitative Analysis Of IVIM In Infarcted Myocardium After STEMI PCI And Normal Myocardium:A Preliminary Study

ObjectiveTo investigate the application of IVIM imaging in the quantitative analysis of infarcted myocardium after STEMI PCI and normal myocardium.MethodsA retrospective analysis method was used to collect 74 CMR imaging health checkups from the First Hospital of Lanzhou University from November 2015 to February 2018.Quantitative analysis of IVIM post-processing software was conducted to investigate the image quality and quantitative evaluation of this scanning imaging technique in normal myocardium.The feasibility study was conducted to statistically analyze the IVIM sequence quantitative indices of perfusion scores(f-values)and true dispersion coefficients(D)for different myocardial segments,different blood supply regions,different ages,and different sex groups in healthy volunteers.There was no statistically significant difference between the value)and the spurious diffusion coefficient(D*value),so that the quantitative assessment of normal myocardium in healthy volunteers could be obtained.To collect 11 patients with acute STEMI from November 2015 to February 2018 in the first hospital of Lanzhou University who underwent CMR examination after?7d and?6m after PCI.Quantitative analysis of IVIM post-processing software was conducted to investigate the technique of the scanning imaging.The feasibility study of image quality and quantitative evaluation of normal myocardium was evaluated to investigate the application of f value,D value and D*value after IVIM post-processing software in quantitative analysis after STEMI PCI.Result74 cases of healthy physical examination score range from 2 to 4 points,an average of 3.17±0.75 points.The f-values,D-values,and D*values of myocardial segments in healthy subjects were not equal(F-values were 5.106,3.349,and 4.130,respectively,P<0.05),and the difference was statistically significant.The mean f-values of left anterior descending coronary artery,right coronary artery,and left circumflex artery blood supply were(0.8898±0.0763)%,(0.8679±0.0993)%,and(0.85115±0.1193)%,and the difference was statistically significant(F value was15.846,P value was 0.000);the average D value of the left anterior descending,right coronary,and left circumflex blood supply regions was(0.0019±0.0010)mm~2/s,(0.0022±0.0008)mm~2/s,and(0.0022±0.0013)mm~2/s.No statistical significance(F value 1.240,P value 0.290);mean D*values of the left anterior descending,right coronary,and left circumflex blood supply regions were(0.0484±0.0245)mm~2/s,(0.0432±0.0166)mm~2,respectively(0.0392±0.0159)mm~2/s,the difference was statistically significant(F=21.903,P=0.000).The image scale scores ranged from 1 to 4 in patients with?7d and?6m after STEMI PCI.There was no significant difference in image quality between the two groups(P<0.05).The f value,D value,and D*value of STEMI after PCI in the?7 d group and the postoperative?6 m group were(0.484±0.2062)%,(0.00154±0.0003)mm2/s,(0.01380±0.0055)mm~2/s,and(0.7185±0.2887)%,(0.0019±.00070)mm~2/s,(0.0285±0.0152)mm~2/s,there was significant difference in f-value,D-value and D*value between different groups.ConclusionThe IVIM imaging examination technique is very feasible and reproducible for myocardial tissue,and the image quality can meet the clinical qualitative and quantitative evaluation of myocardial tissue.The differences in f-values,D-values,and D*values between different segments of the left ventricular myocardium were statistically related to the different coronary blood supply regions of the left ventricular myocardium.IVIM imaging examination technology also has good feasibility and high repeatability in patients after STEMI PCI,which can meet the clinical quantitative evaluation;IVIM imaging examination technology has a better application in quantitative assessment of infarcted myocardium after STEMI PCI.