Clinical Characteristics Of Children With Kawasaki Disease Complicated With Epstein-Barr Virus Infections

Objective:To analyze the clinical features of kawasaki disease(KD)combined with Epstein-Barr virus(EBV)infection and explore the relationship between EBV and KD.Methods:Using retrospective study method,find the KD children in hospital,collecting clinical data of gender,age,clinical manifestation,heating time,intravenous immunoglobulin(IVIG)treatment effect,and related laboratory results include blood routine,blood biochemical indexes,inflammatory indexes,such as C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),procaicltonin(PCT),EBV serological antibody,EBV-DNA,bacteria culture and respiratory pathogens antibody test results,echocardiography results during hospitalization.According to EBV serological antibodies and EB-DNA test results the children can be divided into acute EBV infection group(19 cases),previous EBV infection group(17 cases),no EBV infection group(21 cases),various clinical features were analyzed respectively.Results:1.The hospitalization days of KD children with acute EBV infection were significantly longer than that of the previous infection group and control group(P < 0.05).2.Incomplete KD(IKD)patients have the largest number in the acute infection group,and the chi-square test results were statistically significant(P < 0.05).3.The acute infection group of coronary artery lesions(coronary artery lesions,CAL)incidence rate is higher than that of the other two groups,the results have statistical difference(P < 0.05).4.The inflammatory index of acute infection group was CRP and ESR,which was higher than that of the previous infection group and control group,and the difference was significant(P < 0.05).5.The increase of ALB and ck-mb in the acute infection group was statistically significant,and the CK-MB was significantly different from the control group(P < 0.05).Conclusion:The incidence of IKD increased with acute EBV infection in KD and the hospitalization days of these patients were prolonged.Inflammatory markers,such as CRP and ESR,increased ALB and CK-MB,indicating that patients with acute EBV infection were more inflammatory and more likely to cause vascular injury.