The Preparation Of Transformable Peptide-bis(Pyrene) Nanomaterials For Tumor Diagnostics And Therapy

Targeting diagnostics and therapy of tumor has been paid much attention by researchers.Multifunctional nanoparticles(NPs),especially peptide-based assembled NPs have been widely used due to their good biocompatibility and anti-tumor effect.Bis(pyrene)(BP)is a small organic molecule with aggregate induced emission(AIE)effect.BP shows nearly no emission at monomer state and can emit strong green fluorescence signal at aggregated state.Previous studies revealed that transformable peptide-BP NPs could transform into nanofibers(NFs)under different kinds of stimuli.The biodistribution of NPs in vivo can be real-time observed through the fluorescence signal of BP,which contribute to realize the real-time imaging of tumor site.Peptide-BP NPs can be applied for diagnostics and therapy of tumor.Research shows that tumor growth can be successfully inhibited through anti-angiogenesis drugs or agents.We successfully designed and synthesized a kind of transformable peptide-BP NPs,which could target to overexpressed CD105 of angiogenesis and transform into NFs through ligand-receptor interaction.The morphology of transformable material were measured through transmission electron microscope.NPs showed diameter of 30 nm and NFs exhibited diameter of 8 nm.The peptide-BP NPs can transform into NFs through ligand-receptor interaction,which leading to long term retention in vivo.The retention ability could be measured through fluorescence signal of BP.Meanwhile,nanomaterials were used to testify their anti-tumor effect.The nanomaterials could inhibit tumor growth effectively.This strategy could be utilized to guide the design and preparation of smart nanomaterials for tumor theranostics.