Retrospective Review Of Nutritional Status Of Pediatric Crohn's Disease

Objective:To observe the nutritional status and growth deficiency of children with Crohn's disease(CD);and to describe their distribution characteristics on age,gender,and Montreal classification;and to analyze the causes.Method:Clinical data of 85 children with Crohn's disease in Gastroenterology of Children's Hospital Affiliated to Zhejiang University School of Medicine from February 2008 to December 2014 were retrospectively reviewed.Results:There were 50 males and 35 females in this group,aged 3 months to 16 years(average 9.5±4.9 years).Among them,Fifty-five patients(64.7%)had affected the end of the ileum,77(90.6%)had involved the colon,and 57(67.1%)had involved upper gastrointestinal tract,and 3 had only involved upper gastrointestinal(3.5%),50 cases(58.8%)involved both ileal terminal and colon,16 cases(18.8%)occurred stenosis,5 cases(5.9%)occurred perforation,4 cases occurred both stenosis and perforation(4.7%),10 cases(11.8%)occurred perianal lesions.Among them,21.1%(15/71)of children had limited height growth,43.1%(31/72)of children had different degrees of weight loss,and 64.5%(55/85)of children had anemia.Both were positively correlated with disease activity(P<0.05);45.1%(37/82)of children had hypoproteinemia;the incidence was positively correlated with CRP level and weight loss(P<0.05).31.3%(26/83)of the patients had lower serum calcium levels and had a positive correlation with CRP levels(P<0.05);20%(14/70)had a decrease in serum free iron,33.8%(22/65),zinc deficiency in children with a negative correlation with age(P<0.05);Vitamin D deficiency was found in 54.1%(33/61)of patients,which was positively correlated with intestinal involvement and positively correlated with age(P<0.05);9.8%(6/61)patients had a low serum vitamin B12 level,and 15.7%(11/70)with low folic acid levels.Conclusion:No correlation was found between disease classification and malnutrition indicators,but lack of vitamin D was associated with the presence of small bowel involvement.;young children were more probably to have a zinc deficiency than elder children,and elder children had The proportion of vitamin D deficiency is higher than that of young children.