The Application Of Recombinant Human Erythropoietin Combined With Iron In The Perioperative Blood Management Of Elderly Revision Total Hip Arthroplasty

Objective:Observe the efficacy and safety of recombinant human erythropoietin combined with intravenous iron in the treatment of anemia patients undergoing revision total hip arthroplasty.Method: Retrospectively included clinical data from January 2016 to December 2017 in patients with joint surgery in our hospital diagnosed as primary prosthesis wear or loosening after total hip arthroplasty for a period of total hip revision surgery,according to whether the preoperative use Recombinant human erythropoietin and intravenous iron were divided into treatment group and control group.The observed indicators were preoperative and postoperative detection of hemoglobin and hematocrit in the two groups and comparison of anemia treatment effect,allogeneic blood transfusion and complications between the two groups.Results A total of 52 cases were included in the treatment group 26 cases,12 males and 14 females;the control group 26 patients,11 males and 15 females.Result:There was no significant difference in the preoperative general conditions between the two groups(P>0.05).There was no significant difference in preoperative Hb and HCT between the two groups(P>0.05).The Hb levels on the 3rd and 5th days after treatment in the treatment group were higher than those in the control group,and the difference was statistically significant(P < 0.05).The reduction of Hb and the perioperative blood transfusion rate in the treatment group were lower than those in the control group(P<0.05).Conclusion:Recombinant human erythropoietin combined with intravenous iron therapy can safely and effectively improve hemoglobin levels in anemia patients before total hip arthroplasty,reduce perioperative blood transfusion rates,and promote postoperative functional exercise and rapid recovery.