Study On The Relationship Between Skeletal Muscle Dysfunction And Calpain In Patients With Chronic Obstructive Pulmonary Disease In Different Zang-Fu Deficiency

Objective:By measuring the skeletal muscle content and the concentration of calpain and calpastatin in patients with different disease conditions,different zang-fu deficiency,and different ages of chronic obstructive pulmonary disease,the changes of peripheral skeletal muscle and skeletal muscle dysfunction were observed.The relationship between the condition and COPD,initially exploring the status of skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease and its pathogenesis,in order to provide a basis for functional exercise and other treatment.Mehtods: A total of 120 patients with chronic obstructive pulmonary disease who were eligible for inclusion from April 2017 to February 2018 were collected,and recorded in detail about the general condition of the patients,and pulmonary function tests,MRC scores,CAT scores,and a six-minute walk test were performed.Body composition analysis was performed to measure the skeletal muscle content and body fat percentage and the fat loss index,analysis of the relationship between different zang-fu deficiency and peripheral skeletal muscle content and the occurrence of skeletal muscle dysfunction.All statistical analyses were processed using SPSS 17.0.Reuslts: There were no significant differences in body weight,BMI,FFMI,and six-minute walking distance between patients with chronic obstructive pulmonary disease and COPD patients with different lung function classifications(P>0.05).However,there was a trend of decrease,while the index of dyspnea,The CAT and BODE indices were significantly different(P<0.05).Different zang-fu deficiency had different degrees of skeletal muscle dysfunction in the stable phase of chronic obstructive pulmonary disease.The content of peripheral skeletal muscle and the amount of muscles in the lower limbs were the lowest in the spleen Qi deficiency group,which was more easily associated with skeletal muscle dysfunction(P<0.05).There was no significant difference in the above indexes between the lung Qi deficiency group and the lung-kidney qi deficiency group(P>0.05).The contents of calpain and calpastatin in patients were detected,suggesting differences between lung and spleen qi deficiency group,lung-kidney qi deficiency group and lung-qi-deficiency group(P<0.05);and the concentration of calpain in patients with chronic obstructive pulmonary skeletal muscle dysfunction and uncombined differences(P<0.05),and there was a difference between the two groups in calpain inhibitory protein and calpain ratio(P<0.05).There was no significant difference in BMI,body fat content,total skeletal muscle content,FFMI,limb and trunk skeletal muscle between different age groups(P>0.05),but there was a trend of decreasing with age.Conclusion: Patients with chronic obstructive pulmonary disease have different degrees of skeletal muscle dysfunction,and their degree of occurrence is closely related to the ratio of calpastatin and calpain concentration.The higher the ratio,the more prone to skeletal muscle dysfunction.In the dialectical diagnosis of chronic obstructive pulmonary disease,the skeletal muscle dysfunction in patients with lung spleen qi deficiency was most obvious.Therefore,the theory of “the spleen is responsible for the four limbs and growth of muscles” was confirmed,suggesting that the use of spleen qi and drugs for the treatment of patients with chronic obstructive pulmonary disease The recovery of muscle function may be beneficial.