| Biomaterials of ca-silicate cements,due to its similar chemical composition to bone and good biocompatibility and osteoconductivity,have been applied in clinic as bone repair materials.However,the poor degradation and osteoinductivity limit its further application.With the development of a series technique,especially fabrication techniques,the physicochemical properties of this new bioceramic system has been significant improved.Herein,the osteogenesis capacity and mechanical evolution of the akermanite(Ca2MgSi2O7)porous materials manufactured by ceramic ink writing three-dimensional printing technique were investigated,in comparison with the clinically available β-tricalcium phosphate porous bioceramic.Such 3D printed akermanite scaffolds possess fully interconnected pores of～250 μm in size.And it porosity is over 50%with appreciable compressive strength(72.4±8.5MPa),that is 7-fold higher than that of the β-tricalcium phosphate porous bioceramics(12.5±3.4 MPa).Significant higher cell proliferation,alkaline phosphatase acitivity and mRNA expressions of osteogenic genes were detected in the akermanite group.These results suggest that the mechanically strong 3D printed akermanite scaffolds are promising for the bone tissue regeneration. |
