The Effect And Comparation Of Commonly Used Liver-Protection Drugs For Human Hepatocytes HL-7702 After Irradiated By X Ray

Objective:To investigate the effect of different mechanisms of liver-protection drugs in clinic and compare which one is best for the proliferation of irradiated HL-7702,laying the basis of liver-protection drugs choose in clinic on theory and practice.Methods: 1.Human liver parenchyma cells HL-7702 were given single 6 MV X ray irradiation at a dose of 10 Gy,the cells' morphology were detected.2.MTT was used to assess the survival rate of the cells to evaluate the effect of the X ray.The representive medicines which mechanism may relate to RILD were chosen.Different concentrations of medicines were used to protect the cells damaged by the X ray.3.Comparing the effect with MTT and measure SOD,MDA for the best one.Further research on its protection of oxidative damage.Results: Magnesium isoglycyrrhizinate have abvious effect on the proliferation of liver cells(P<0.05).Conclusions: 1.In three kinds of representing medicines,magnesium isoglycyrrhizinate has preferable effects on liver parenchyma cells and show a bright future in the treatment of RILD.The effect rate of magnesium isoglycyrrhizinate can reach 38.58%,the second is polyene phosphatidyl choline,effective rate was 11.6%.2.The protection of magnesium isoglycyrrhizinate mainly reflects in the aspect of cell proliferation.3.Classic liver-protection drug reduced glutathione did not show obvious effect in RILD.