High Does Of The Clopidpgrel Drugs On Polymorphisms Gene-type In Clopidpgrel CYP2C19 * 2?* 3 Unfunctional Alleles Between Ethnic Han And Uygur After Undergoing PCI And Following Up MACE Events

Objective:Although some clinical exports recommend that to those patients who carried at least one LOF allele on treatment of using clopidogrel had better to take double does of it,there is some controversy regarding of some genes such at CYP2C19 polymorphisms genotype on clinical outcome in patients who were receiving the Aspirin and clopidogrel(the dual anti-platelet therapy,DAPT).We hypothesized that those kinds of genotype have some relationship different from the Han and Uygur nation patients who were undergoing the Percutaneous Coronary Angiography and Coronary stent implantation(PCI).The aim of this study was to evaluate the rate of the adverse cardiovascular events following coronary stent implantation in patients who had different ethnic with any those three kinds of genotype.Methods:A total of 369 acute coronary syndrome patients who were undergoing the PCI of different ethnicity on clopidogrel regime were enrolled.All of patients before PCI were taken loading dose of 300 mg Aspirin and 300 mg clopidogrel,after PCI patients were all took aspirin 100 mg/day,according to testing their genes after undergoing percutaneous coronary intervention(PCI)72h and adjusting the does of clopidogrel,we made those patients into two groups:clopidogrel 75mg/day and clopidogrel 150 mg/day,with following up 1 years to evaluating the MACE happening.Results: Whatever the clopidogrel 75 mg/day group and clopidogrel 150mg/day group,there is no significant between Han ethnicity and Uygur ethnic groups in cardiovascular event with following up,Chi-square analysis demonstrated that the safety between two groups in high does of group is same with the normal does.Conclusions: Our finding indicated that in the western part of China especially in the muti-enthnic-populated areas such as Uygur ethnic groups in xinjiang urumqi,Uygur ethnic groups have nohigher probability of cardiovascular event than Han ethnic groups.The treatment of receiving the Aspirin and clopidogrel(the dual anti-platelet therapy)should be Individualized and better to test genes in muti-enthnic-populated areas in rural China.