Correlation Between Subchondral Bone And Osteoarthritis In Postmenopausal Woman

Objective:To investigate the correlation between subchondral bone and The osteoarthritis in postmenopausal women.Methods:The study participants were 100 patients with knee osteoarthritis in postmenopausal woman who attended The First Affiliated Hospital of Xinjiang Medical University from July 2017 to October 2017,aged 45~92(65.17±10.92)years.According to the Kellgren&Lawrence grading standard grades ?,?,?,? of KOA were divided into four groups,such as A,B,C and D.The regions of interest(ROI)were place in the medial and lateral compartments of tibial subchondral bone.Bone mineral density(BMD)of each ROI was measured by dual-energy X-ray absorptiometry(DXA).as the same time,BMD of lumbar spine and femoral neck were measured.Results:In the 100 cases of primary KOA patients,mean ROI 1 BMD was(0.656±0.245)g/cm2,mean ROI 2 BMD was(0.459±0.197)g/cm2,mean lumber spine BMD was(0.762±0.154)g/cm2,and mean femoral neck BMD was(0.751±0.139)g/cm2.Comparison BMD of ROI 1,ROI 2,femoral neck and lumber spine with degree of KOA.found that there were statistically difference BMD of ROI 1,ROI 2,femoral neck between the four groups(P < 0.05);there was no statistically difference BMD of lumber spine between the four groups(P?0.05).Correlation BMD of ROI 1,ROI2 with degree of KOA,age,BMD of femoral neck and lumber spine.found that The BMD of ROI 1,ROI2 was negatively correlated with degree of KOA and age(r=-0.430 P=0.00,r=-0.244 P=0.029;r=-0.509 P=0.00,r=-0.509 P=0.001),was positively correlated with BMD of lumbar spine and femoral neck(r=0.386 P=0.00,r=0.367P=0.001;r=0.415 P=0.00,r=0.447 P=0.00).Conclusion:With the development of KOA,we found the presence of endplate sclerosis in subchondral bone cortex of tibia,as well as osteoporosis in cancellous bone.