Value Of Four-dimensional Strain Imaging In The Prediction Of Left Ventricular Function Improvement Of Coronary Heart Disease After Percutaneous Coronary Intervention

Objective The aim of this study was to clarify the role of the newly developed four-dimensional strain imaging(4D-SI)in the prediction of left ventricular functional improvement after percutaneous coronary intervention(PCI).Methods 55 patients diagnosed with coronary heart disease(CHD)by coronary angiography and successfully underwent PCI were recruited.After 6 monthes follow up,the CHD patients were grouped into function improvement group and non-function improvement group based on whether having left ventricular function improvement or not.Before and after PCI,left ventricular end-systolic volume(LVESV),left ventricular end-diastolic volume(LVEDV)and left ventricular ejection fraction(LVEF)by echocardiography,the global longitudinal peak strain(2D-GLPS)by strain imaging using Automated Function Imaging(AFI),global longitudinal peak strain(4D-GLPS),circumferential peak strain(4D-GCPS),radial peak strain(4D-GRPS)and area peak strain(4D-GAPS)by 4D-SI were assessed.Results Before and after PCI,all LV strain values of function improvement group were higher than those of non-function improvement group(P<0.001);the single parameter mode of ROC curve analysis showed that the area under the ROC curve(AUC)(0.944),sensitivity(91.3%)and specificity(93.8%)of 4D-GAPS arerelatively higher than other strain parameters.The single technology mode of ROC curve analysis showed that AUC(0.969),sensitivity(95.7%)and specificity(90.6%)of 4D-SI were higher than the AFI-based longitudinal strain.Conclusion 4D-SI is a more accurate and comprehensive method in the prediction of the LV myocardial function recovery,and 4D-GAPS and 4D-GCPS,anovel automatic index,can act as an independent predictor in LV myocardial function recovery.