Effects Of Swimming Training Combined With Buyang Huanwu Decoction On The Expression Of Nogo-A?BDNF And VEGF After Spinal Cord Transection In Rats

ObjectiveTo observe the effect of swimming training combined with Buyang Huanwu Decoction on changing the expression of Nogo-A,BDNF and VEGF in the injured spinal cord,and study the subsequent primary recovery mechanism of the spinal cord transection in the rat.MethodsCopy and evaluate rat model after spinal cord injury(SCI).150 rats were randomly divided into 5 groups: SCI group,SCI + swimming training group(swimming group),SCI + Buyang Huanwu Decoction group(Chinese traditional medicine group),SCI + swimming training + Buyang Huanwu Decoction group(combination group),sham operation group.Detected the expression of Nogo-A,BDNF and VEGF at 1w(7d)?2w(14d)?3w(21d)?4w(28d)?5w(35d)five time points.The rats in each group were given BBB score at all time points after the operation.ResultsThe scores of BBB were increased(P<0.05)in each treatment group at different time points respectively.Comparing with the SCI group,the expression of BDNF and VEGF was significantly increased and the expression of Nogo-A was significantly decreased in the swimming group,Chinese traditional medicine group and combination treatment group(P<0.05).Furthermore,the expression of BDNF and VEGF was significantly increased and the expression of Nogo-A was significantly decreased in the combination treatment group when compared with the swimming group and Chinese traditional medicine group at 7d?14d?21d?28d?35d(P<0.05).Conclusions 1.Swimming training and Buyang Huanwu Decoction treatment can increase the data of BDNF and VEGF and decrease the data of Nogo-A in the most significant of the transection lesion in the spinal coard rats model that damaged pathomorphology.2.Buyang Huanwu Decoction combined with swimming training treatment is more effective for the recovery of motor function.