| Objective To evaluate the value of superparamagnetic iron oxide-enhanced magnetic resonance imaging in the diagnosis of focal liver lesions by meta-analysis.Methods Pubmed,EMbase,The Cochrane Library and CNKI databases were searched systematically for English and Chinese language articles related to the aim of exploring the Diagnostic value of superparamagnetic iron oxide-enhanced MRI for focal liver lesions,all the articles searched were published before April 30,2017.Meta-Disc 1.4 software was used for meta-analysis,the funnel map was drawn and the publication bias was evaluated by using Stata12.0 software.two reviewers who independently screened the literature according to the inclusion and exclusion criteria,extracted the data and evaluated the quality of the included studies.Results A total of 15 diagnostic studies were included in this meta analysis,with a total of 958 lesions.Meta analysis showed that the sensitivity and specificity of this method to detect hepatocellular carcinoma were 85%and 78%,respectively,in the identification of hepatocellular carcinoma and other liver focal lesions.After excluding non-hepatic malignant tumors,The sensitivity did not change and the specificity increased to 87%.In the differential differentiation and poorly differentiated hepatocellular carcinoma,the sensitivity of this method to detect poorly differentiated hepatocellular carcinoma was 98%,the specificity was 50%,and the area under the SROC curve(AUC)was 0.97.In the differential differentiation of hepatocellular carcinoma and atypical hyperplasia nodules,this method detects the sensitivity and specificity of well-differentiated hepatocellular carcinoma by 50%and 92%,respectively,and the area under the SROC curve is 0.80.Conclusion Superparamagnetic iron oxide-enhanced MRI is valuable in differentiating hepatocellular carcinoma and other liver focal lesions. |
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