Non-steroidal Anti-inflammatory Drugs Use And The Risk Of Death In Patients With Lung Cancer:A Meta-analysis Of Five Prospective Cohort Studies

Background:Non-steroidal anti-inflammatory drugs(NSAID)has been gaining increasing attention as a potential therapeutic agent against lung cancer.Previous studies have showed conflicting results regarding the effect of NSAID on risk of death in lung cancer.The present meta-analysis aims to explore the relationship between NSAID and lung cancer mortality by summarizing prospective cohort studies in this field.Method:A systematic literature search was conducted in Embase,Pubmed and Cochrane Library databases for articles between Jan 2011 and Apr 2017.Identified studies were then reviewed manually to determine if they meet with the a priori inclusion criteria.Five prospective studies were identified and included in this meta-analysis.The Random-Effect Model was used to assess the pooled hazard ratio(HR)and between-study heterogeneity was assessed using I~2 index and Cochran Q test.Subgroup analysis,meta-regression,as well as sensitivity analysis was performed to pinpoint the exact sources of the observed heterogeneity.Results:Five studies with a total of 6017 lung cancer patients were included in the final meta-analysis.In general,NSAID use can reduce altered mortality in lung cancer.The pooled HR was 0.88[95%confidence intervals(CI)0.73 to 1.05.The heterogeneity between studies was low(Q=6.95;I~2=42.4%,P=0.139).And Egger(p=0.665)and Begg's(p=1.000)test showed little publication bias.Conclusion:NSAID use can reduce the HR of lung cancer and improve overall survival was found.