The Effects Of Shexiang Baoxin Pill And Nicorandil On Myocardial Perfusion And Short-Term Prognosis In Patients With ST-elevation Myocardial Infarction Who Are Belong To Qi Deficiency And Blood Stasis Stype

Objective:To observe the effect of Shexiang Baoxin Pill combined with intra-coronary injection of nicorandil on myocardial perfusion and short-term prognosis after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction who belong to Qi Deficiency and Blood Stasis stypeMethods:Choose to observe the hospital cardiovascular surgery in January 2016 to January 2017 underwent PPCI of Qi Deficiency and Blood Stasis stype STEMI patients were 151 cases.They were randomly divided into three groups.In the conventional treatment group(group a)were 51 cases.There were 50 patients underwent intra-coronary injection of nicorandil(group b)and 50 patients underwent intra-coronary injection of nicorandil +preoperative oral Shexiang Baoxin Pill(group c).The group a were conventional treatment group,who were intra-coronary injected 2-6 mg of normal saline in PPCI.The group b were intra-coronary injected 2-6 mg of nicorandil in PPCI.The group c were intra-coronary injected 2-6 mg of nicorandil in PPCI+ preoperative oral Shexiang Baoxin Pill 2 pills,and within 24 hours after PPCI by "2 pills,3 Times/day "dose began to oral application of Shexiang Baoxin Pills.Results:The age of the patients was 61.92±10.66 years old,including 126 males and 83.4%of the total.There was no significant difference in sex,age and risk factors of coronary heart disease,RGB,BNP,NEUT among the three groups(P>0.05).There was no significant difference in TIMI grade 3 blood flow ratio,the number of infarct-related vessels,the thrombosis points,the number of tirofiban used,SO-T-B and DO-T-B among the three groups(P>0.05).There were significant differences in the number of cTFC frames count,,the incidence of 2-hour-ECG ST segment drop>50%among the three groups(P<0.05).There were no significant differences in cardiovascular death,malignant arrhythmia,heart failure and revascularization between the three groups(P>0.05).There were significant differences in angina pectoris within 3 months after PPCI(P<0.05).There were no significant difference in cardiovascular death,chronic heart failure or heart failure increased and revascularization within 3 months postoperatively(P>0.05).Conclusion:Shexiang Baoxin Pill combined with intra-coronary injection of nicorandil can improve myocardial perfusion and short-term prognosis after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction who belong to Qi Deficiency and Blood Stasis stype.