Multivariate Analysis Of Pathological Complete Regression After Neoadjuvant Therapy In ??? Midterm Low Rectal Cancer

Objective:There were individual differences in the efficacy of neoadjuvant therapy.Tumor regression grading was closely related to the prognosis of patients,and pathological complete regression(pCR)was the most ideal result.The aim of this study was to identify clinical factors that could predict pCR to offer patients a better individual therapy for rectal cancer.Methods: The study involved 65 patients with rectal cancer who underwent neoadjuvant therapy between January 2012 to December 2016 at the First Affiliated Hospital of Soochow University,and evaluated the pathological changes of tumor tissue.Logistic regression methods was used to analyze the clinical factors associated with pCR.Results:There were 12 patients with pCR after neoadjuvant therapy,accounting for 18.5% of the total number.Univariate analysis showed that the CEA level and total radiotherapy were correlated with pCR(p<0.05).The mean number of lymph nodes of the patients with pCR was 8,with a metastasis rate of 8.3%;The mean number of lymph nodes of the patients with non pCR was 9,with a metastasis rate of 43.4%.Conclusion:1.The pretreatment CEA and total radiotherapy of the patients who underwent neoadjuvant therapy were the mosr important clinical factor of pCR.2.The number of lymph nodes after neoadjuvant therapy was less than 12,and the lymph node metastasis rate with pCR patients was lower than that the non p CR patients.