| Objective:To study the association between aortic dilation and hypertensive patients by transthoracic two-dimensional echocardiography and the correlation with the left ventricular morphological function.Methods: To assess aotic dimensions in hypertensive patients,221 patients with hypertension and 153 non-hypertensive volunteers from November 2016 to February 2017 were prospectively enrolled.Comprehensive echocardiography and blood biochemical examination were received for these patients.Ages of Hypertension group were 31-91 years.Mean age was 66.0 ± 10.9 years.The average age of men was 65.73 ±10.73 years,and the average age of women was 66.36±11.24 years.Ages of controlled group were 16 to 85 years.The average age was 56.36 ±15.95)years.The average age of men was 57.61±15.04 years,and the average age of women was 66.36 ±11.24 years.Diameters in aortic annulus,sinuses of Valsalva,sinotubular junction,ascending Aorta,aortic arch,descending aorta and abdominal aorta were measured in both two groups of patients.We also measured other echocardiographic parameters including interventricular thickness(IVS),left ventricular diastolic dimension(LVDd),left ventricular systolic dimension(LVDs),left ventricular posterior wall thickness(LVPWd),peak transmitral early(E)and late(A)velocities,early deceleration time(DT)by pulsed-wave Doppler and early(e’)diastolic velocities by tissue-Doppler interrogation of the septal and lateral margins,thus E/A,left ventricular ejection fraction(LVEF)were calculated.Clinical information were collected including gender,age,height,weight,blood pressure,history of hypertension,smoking history,history of diabetes and the hypertensive drugs.Blood total cholesterol(TC),low density lipoprotein(LDL),triglyceride(TG),uric acid(UA)and creatinine(CR)were also recorded.The hypertension group and control group were divided into <60 years old and > 60 years old Or men and women.The association between age and aorta dilation was observed.Results: Weight and body mass index(BMI)of baseline Characteristics were higher than that of control group.The number of smoking,and diabetes significantly increased in hypertension group than in control group.Uric acid(UA)and serum creatinine(CR)of hypertension group also significantly increased than in control group.In addition to the hypertension group E,E/A and e’,other echocardiographic parameters in hypertension group were lower than those of control group.The internal diameter of the aorta and ascending aorta was significantly associated with the thickness of the left ventricular septum and the quality of the left ventricle.Compared with controlled group,diameters in aortic annulus(21.1±2.0mm vs 20.3±2.1mm,P<0.05),sinuses of Valsalva(35.0±4.0 mm vs 31.9±3.9 mm,P<0.05),sinotubular junction(28.2±3.6 mm vs 27.0±3.2 mm,P<0.05)、ascending Aorta,,and(37.3±4.6 mm vs 32.9±4.4 mm,P<0.05)、aortic arch(27.6±4.6 mm vs 25.4±3.3 mm,P<0.05)、descending aorta(21.9±3.0mm vs 20.3±2.9mm,P<0.05)、abdominal aorta(20.9±2.7mm vs 19.2±2.7mm,P<0.05)were significantly increased in hypertention group.Among these,ascending Aortic dilated obviously,followed by aortic arch.Considering of gender difference,men’s aorta measurements were greater than t women’s both in high blood group and control group.There was a significant correlation between increased aorta and left ventricular structures。Conclusions: Systematic analysis of the aorta in hypertensive patients showed that,together with age,gender,and body surface area,hypertension is an independent factor associated with increases in all seven aortic diameters and that aortic dilation occurred more frequently at the level of the sinuses of Valsalva and ascending aorta. |
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