Predictive Factors Of Early Arterial Reocclusion After Thrombolysis In Acute Ischemic Stroke

Objective:To investigate the predictive factors of early reocclusion(RO)in stroke patients treated with intravenous recombinant tissue-plasminogen activator(rt-PA).to explore the correlation between lipoprotein(a)and carotid intimal thicken and plaque formation in patients with ischemic cerebrovascular disease.Methods:The patients treated with intravenous thrombolysis were enrolled retrospectively.According to the NIHSS(National Institute of Health Stroke Scale)within 24h,they were divided into either a recanalization group(2-point improvement on NIHSS without any deterioration followed)or a RO group(any 2-point deterioration on the NIHSS after an initial 2-point improvement after treatment).Univariate analysis and multivariate logistic regression analysis were used to compare and analyze the demographic data,vascular risk factors,clinical data,laboratory data and imaging data,mRS at Discharge time.The predictive factors for RO were identified.Results:A total of 81 patients treated with intravenous thrombolysis were enrolled,including 18 patients(22.2%)with RO and 63 patients(77.8%)with constant recanalization.There were significant differences in the fibrinogen(t=2.428,P=0.019),D-dimer(t=3.017,P=0.003)and mRS(Z=-2.236,P=0.025).Multivariate logistic regression analysis showed that D-dimer(odds ratio[OR]0.995,95%confidence interval[CI]0.990?1.000;P = 0.049)was the independent predictive factor for RO after thrombolytic therapy.Conclusion:Reocclusion is associated with a trend toward poor outcome.D-dimer content is the predictive factor of early reocclusion after intravenous thrombolysis.