Synthesis And Properties Study Of 3D Real-time Radiation Scintillation Hydrogel Material With Tissue Equivalence

The precise verification of radiation dose plays an important role in radiotherapy,however,present methods still cannot satisfy the requirements of fast and accurate dose measurement.Tissue equivalent radiation scintillation material is the ideal material for fast and accurate 3D dose measurement,and it is a popular research topic in radiation dose verification technology.Three methods were studied in this work,in which 3D real-time radiation scintillation hydrogel materials with tissue equivalent were prepared.2,5-Diphenyloxazole(PPO)is loaded on polyacrylamide/polystyrene nano-microspheres composite hydrogel that is prepared by using one-step radiation method.The study found that the introduction of the polystyrene nano-microspheres could improve the stability of hydrogel.Compared to the PS/PAAm composite hydrogel,the prepared radiation scintillation hydrogel displays radiation infiltrating emitting blue light under ultraviolet.Meanwhile,PPO is successfully adsorption on the surface of PS/PAAm composite hydrogel,which can be proved by SEM analysis.Radiation load method is used to prepare the uniform radiation scintillation hydrogel material.Firstly,PPO was loaded on water-soluble Polystyrene(PS)hollow microsphere by stirring in radiation scintillation microspheres solution.And then acrylamide is added in the mix solution,and the hydrogel material is obtained using radiation crosslinking technology.The water-soluble PS hollow microspheres are prepared by free radical polymerization and self-assembly reaction(IFPS)method.The results show that PPO is successfully loaded on PS hollow microspheres,and the composite microspheres can be well dispersed in aqueous solution.PPO was more uniform distributed in radiation scintillation hydrogel material.PPO was loaded on the PS hollow microsphere with chemical bonds by IFPS,and then the uniform stability scintillation hydrogel material obtained by using radiation method.The two-step radiation method can solve the defect of the weakness of Van Der Waals forces.PS/PPO fluorescent microspheres are obtained by using IFPS firstly,then acrylamide is added in PS/PPO fluorescent microspheres aqueous solution to obtain radiation scintillation hydrogel material by radiation.The results show that the emitted wavelength of PS/PPO fluorescent microspheres red shifts to visible light region,which is more convenient to the data acquisition of dose measurement.In addition,the prepared hydrogel demonstrates good luminous performance.