The Role Of Erbin Regulating Er? Signaling In Hepatocellular Carcinoma

Hepatocellular carcinoma(HCC)is one of the most prevalent cancers in the world.Hepatocellular carcinoma has a gender difference,the incidence of HCC in males is 2 to 11-fold higher than in females,and the male patients with HCC usually have a poorer prognosis than female patients with HCC,suggesting the roles of sex hormones and their receptors in HCC.However,The mechanism by which hepatocellular carcinoma is regulated is still unclear.Thus,it is important to investigate the mechanism of HCC development and progression and to find effective targets for treatment of hepatocellular carcinoma.Recent studies suggest that abnormal expression and function of estrogen receptor ?(ER?)is implicated in HCC.However,it is unclear that how ER? is regulated in the development of HCC.Herein,we aimed to identify a new mechanism that ER? signaling is regulated in HCC,which may lead to a potential new strategy for HCC therapy.Our data uncovered an important role of Erbin in regulating HCC tumorigenesis.Erbin inactivated ER?-mediated tumor-suppressive signaling,acting to enhance binding of CHIP to ER? via its interaction with ER? and thereby promoting ubiquitination and degradation of ER?.This study suggests a new strategy for tamoxifen therapy in HCC by targeting Erbin/ER? signaling axis.