Effect Of Preventing BPD In Premature Infants With RDS Bydexamethasone On N-terminalpro-brain Natriureticpeptide Level

Objective To understand effect of dexamethasone(DXM)in process of preventing severe respiratory distress syndrome(RDS)premature infants bronchopulmonary dysplasia(BPD)on plasma N-terminal pro-B-type natriuretic peptide(NT-proBNP)level.Methods To select premature infants treated by NICU from December 2014 to October 2016 of Chenzhou Hospotal Affiliated to South China University,who were characterized by gestational age?32W,birth weight?1500g,by respiratory support,severe RDS(III-IV),They were divided into weaning group and non-weaning group according to whether they relied on respirator after 14 days from birth,among which non-weaning group was divided into DXM treatment group and DXM non-treatment group according to whether they were treated by DXM.All infants were divided into BPD group and non BPD group according to whether they were diagnosed as BPD.All premature infants were collected veinal blood after 14 d and 28 d from birth,to test plasma NT-proBNP level by immunochromatography assay,and compared with different groups inter and intra groups,to analyze effect of DXM on plasma NT-proBNP level as well as relevance of plasma NT-proBNP level and BPD.Results(1)There were statistical significance in the level of plasma NT-pro BNP on 14 days after birth between weaning group and non-weaning group(P<0.05).(2)There were no statistical significance in the level of plasma NT-proBNP on 14 days after birth between DXM treatment group and DXM non-treatment group(P>0.05),on 28 days after birth,there were no statistical significance(P<0.05).(3)The level of plasma NT-proBNP in DXM treatment group on 28 d after birth was less than that on 14 d after birth,there was statistical significance(P < 0.05).The level of plasma NT-proBNP in DXM non-treatment group on 28 d after birth was less than that on 14 d after birth,there was no statistical significance(P>0.05).(4)28d after birth,the level of plasma NT-proBNP in BPD group of DXM treatment group was higher than that in non-BPD group,there was statistical significance(P<0.05).28 d after birth,the level of plasma NT-proBNP in BPD group of DXM no-treatment group was higher than that in non-BPD group,there was statistical significance(P<0.05).(5)The incidenceofBPD(36.67%)in DXM treatment group was less than that in DXM non-treatment group(68.42%),the incidence of moderate/severeBPD(11.54%)in DXM treatment group was less than that in DXM non-treatment group(41.18%),there were statistical significance(P<0.05).(6)28d after birth,the plasma NT-proBNP in mild BPD group was less than that in moderate/severe BPD group,there was statistical significance(P<0.05).Conclusions(1)Dexamethasone can reduces the incidence and severity ofBPD,and the level of plasma NT-proBNPin premature infants with severe RDS.(2)Plasma NT-proBNP levels were associated with BPD occurrence and severity,dynamic monitoring its changes in clinical practice,provide reference to evaluate BPD occurs and its severity.