Determinants And Regression Equations For The Calculation Of Z-scores Of Left Heart Structures In A Healthy Han Chinese Adult Population

Background:Decision making in the care of patients with congenital and acquired heart disease remains reliant on detailed measurements of cardiac structures using 2-diameteral echocardiography.Calculated z scores are often used to normalize these measurements to different measurements in pediatric patients.However,the determinants of left heart structures in adults are rarely repoted.Objective:We investigated the predictors of left heart(LH)structures in a healthy Chinese Han adult population and established normative data and regression equations for the calculation of Z-scores.Methods:Two-diameteral and M-mode echocardiography was performed in 605 patients ranging in age from 18 to 80 years(age of 44.41±13.6 years,43.6%female).6 routine left structures measurements(AOD?LAD?LVDd?LVDs?IVSTd?LVPWd)were determined.Data are presented graphically,and regression equations are derived relating cardiac diameter to the most important determinants with calculating Z-scores.Results:Body surface area(BSA)was the strongest determinant of left heart cardiac strucutres.(AOD:R=0.42,P<0.001;LAD:R=0.43,P<0.001;LVDd:R=0.69,P<0.001;LVDs:R=0.56,P<0.001;IVSd:R=0.32,P<0.001;LVPWd:R=0.36,P<0.001),BSA-specific reference ranges,regression equations,and scatterplots for the calculation of z scores were determined for each index.Conclusion:BSA is the strongest determinant of LH structures in Chinese Han adults.The availability of BSA-specific normality data for the calculation of Z-scores may allow for correctly detecting congenital and acquired heart disease.