Myocardial Infarction Promoted The Contrast-induced Nephropathy By Renal Injury

Background:The morbidity of myocardial infarction is keeping raise in this decade.Because of high safety and operability,percutaneous coronary intervention(PCI)has been used to conquer this disease for more than 20 years.An important complication of PCI is contrast induced nephropathy(CIN),which raises our attention.In this study,we investigate the role of acute myocardial infarction in the pathogenesis of CIN.Methods:In this study,forty male rats were randomly divided into four groups:control group(n=8),CM group(n=12),AMI group(n=8)and AMI+CM group(n=12),then velocity of renal artery blood flow(VRABF),computer tomography(CT),serum creatinine(Scr),reactive oxidative species(ROS),periodic acid-Schiff(PAS)and TUNEL were used to estimate the injury of kidney.Results:The data showed that VRABF was lower in AMI+CM group than CM group and CT number in cortex was higher in AMI+CM group than CM group at 4-hour.As well as the level of Scr in AMI+CM group displayed a significantly increase at 24-hour compared with CM group.The histopathologic scores and percentage of tubular cell apoptosis were higher in AMI+CM group at 24-hour.Conclusion:Compared to the elective patient,the injury of CIN exhibited a higher severity in AMI patient.