Lipasin Levels Were Increased In Type 2 Diabetes Mellitus With Vascular Complications And Pregnant Women With Or Without Gestational Diabetes Mellitus

Background: Diabetic vascular complication is quite common and is the leading cause of death in patients with type 2 diabetes.Diabetic retinopathy(DR)is one of the major microvascular complications of diabetes and cardiovascular disease(CVD)is one of major macrovascular complications of diabetes.The incidence of gestational diabetes mellitus is increasing year by year all over the world,especially in developing countries.It is a common perinatal complication which can threaten maternal and child health and even lead to energy metabolism disorders in pregnant women.Lipasin also known as angiopoietin-like protein 8 is a novel blood lipid regulator and has been recognized as an angiopoietin-like(ANGPTL)family member.In recent reports,Lipasin was found to be linked with lipid metabolism,β-cell mass and glucose homeostasis.Methods : There were 124 type 2 diabetes patients in the study of vascular complications of diabetes.These patients were divided into groups:diabetic retinopathy group(n=23),cardiovascular disease group(n=22)and control group(n=79).There were 49 pregnant women and 31 age-matched women in the study of gestational diabetes mellitus.These women were divided into groups:un-pregnant women with normal glucose regulation(n=31),pregnant women with normal glucose regulation(n=27)and gestational diabetes mellitus(n=22).Serum Lipasin concentrations were measured by enzyme linked immunosorbent assay.Results:Serum Lipasin levels were significantly higher in participants with vascular complications than in without vascular complications subjects(P< 0.05).Logistic regression showed that lipasin was the only variable which was significantly and independently associated with retinopathy(OR=2.54,P = 0.020).Patients with CVD had significantly higher ANGPTL8 levels compared with those without(P = 0.022).After adjustments for conventional CVD risk factors,a quartile increase of ANGPTL8 level conferred 2.01-fold higher odds ratio of CVD(OR=3.02,P = 0.035).In type 2 diabetes patients,serum Lipasin was correlated with TC(r=-0.354,P=0.003)and LDL(r=-0.32,P=0.006).The P-NGR group had almost 4 times more Lipasin than those of the UP-NGR group(1,513.6 [696.4–2,178.8] versus 283.3 [182.8–303.4] pg/mL,p< 0.0001).Spearman correlation analysis revealed that Lipasin levels were positively and significantly associated with TC,TG,HDL-c,FINS.Conclusions:Type 2 diabetes patients with cardiovascular disease have remarkably higher levels of Lipsin.Lipasin is regarded not only as a lipid regulator but may also be a new biomarker for diabetic retinopathy.Lipasin levels were remarkably higher in pregnant women when compared with those in un-pregnant women.