Association Vitamin D Levels With IL-6?CRP?MCP-1 On Peritoneal Dialysis Patients

Objective 1?1.Investigate the serum levels of 1-2,5,dihydroxy vitamin D3(1-25(OH),2D3)(D)in patients with end-stage renal disease undergoing peritoneal dialysis.2.Investigate the relationship between vitamin D levels and inflammatory factors MCP-1,IL-6 and CRP in patients with end-stage renal disease and peritoneal dialysis.Methods 1.From September 2015 to September 2016 were randomly selected from the Hunan People's Hospital nephrology in end-stage renal disease patients with peritoneal dialysis in 70 cases for the experimental subjects(excluding patients with peritoneal infection,antibiotics,diabetes,hepatitis,cancer,autoimmune dysfunction,etc.Drugs that have an immediate effect on autoimmune function are excluded.Venous blood samples were collected and vitamin D was detected and isolated.The remaining serum was stored in a-80 temperature refrigerator,and the levels of inflammatory factors MCP-1,IL-6 and CRP were detected by enzyme-linked immunosorbent assay(ELISA)in three groups.According to the standard,the detected vitamin D content was divided into two groups,that is vitamin D normal group(VitD>30ng/L)and vitamin D deficiency group(VitD<30ng/L)(According to the 2011 International Endocrine Society guidelines for the prevention and treatment of vitamin D deficiency,3 were deficient in vitamin D,and have been eliminated).2.To investigate the relationship between vitamin D levels and inflammatory cytokines MCP-1,IL-6,and CRP,in peritoneal dialysis patients.Results 1.A total of 70 patients with peritoneal dialysis were included in this study.According to the vitamin D level before peritoneal dialysis,they were divided into two groups,of which the normal group of vitamin D accounted for 37.1%,and the group of vitamin D deficiency was62.9%.The difference between the normal vitamin D group and the vitamin D deficiency group was statistically significant(P<0.05).2,IL-6,CRP content,vitamin D in the normal group was lower than the vitamin D deficiency group,and the difference was statistically significant(P<0.05);the MCP-1 vitamin D normal group and the vitamin D deficiency group were not statistically significant(P>0.05).Conclusion Most of the patients with end-stage renal disease have vitamin D deficiency.2,IL-6 and CRP in patients with end-stage renal disease were negatively correlated with vitamin D levels,and no correlation with MCP-1.