Effect Of Smoking On The Level Of Plasma NT-proBNP In Patients With Chronic Heart Failure

Objective:To investigate the relationship between some factors,especially smoking,and plasma N-terminal pro-B-type natriuretic peptide(NT-pro BNP)level in patients with chronic heart failure.Methods:113 patients with chronic heart failure hospitalized in the Department of Cardiology of Shanxi Provincial People's Hospital were recruited to the study.Commom items including age,sex,body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),cardiac function,history of present and past illness,smoking and alcohol consumption as well as biochemical indexes including fasting plasma glucose(FPG),total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-c),low density lipoprotein cholesterol(LDL-c),alanine aminotransferase(ALT),aspartate aminotransferase(AST),serum creatinine(Scr),blood urea nitrogen(BUN),hemoglobin(Hb),and NT-pro BNP were recorded.The patients were classified into 3categories based on self-reported smoking habits: current,former,and never smokers,commom items and biochemical indexes were compared between the three groups.The relationship between age,gender,smoking and alcohol consumption,BMI,FPG,TG,TC,HDL-c,LDL-c,SBP,DBP,cardiac function,history of present and past illness and plasma NT-pro BNP level was analyzed using multiple linear regression.Results:(1)The plasma NT-pro BNP level in the three groups has significantly statistical difference(P<0.05),and the differences between every two groups also reach statistical significance(P<0.05).The plasma NT-pro BNP level of the current smoking group is much higher than the other two groups,and the former smoking group is higher than the never smoking group.There are no significant differences in BMI,HDL-c,ALT,AST,Scr,BUN,WBC,Hb,Plt,SBP,DBP and cardiac function of the three groups(P>0.05),but the age,sex,FBG,TC,TG,LDL-c in the three groups have statistical differences(P<0.05),and the differences between every two groups also reach statistical significance(P<0.05).(2)Multiple linear regression analysis is performed by using age,gender,smoking and alcohol consumption,BMI,FPG,TG,TC,HDL-c,LDL-c,SBP,DBP,cardiac function,history of present and past illness as independent variable and plasma NT-pro BNP level as dependent variable,and it turns out to be that factors associated with plasma NT-pro BNP level are age and cardiomyopathy(P < 0.05).Conclusion:(1)Smoking is an important risk factor for elevated plasma NT-pro BNP level.(2)The average onset age of heart failure in the current smoking group is 15 years earlier than the never smoking group.(3)The other factors associated with plasma NT-pro BNP level are age and cardiomyopathy.(4)The level of NT-pro BNP increases with age,but the age of current smoking group is lower than the other two groups,while the NT-pro BNP level is higher,suggesting that smoking is likely to aggravate the severity of heart failure.