Multivariate Regression Analysis Of WHO ? Meningiomas Postoperative Recurrence

Objective:(1)To investigate the clinical,imageology and histological characteristics of WHO? meningiomas,and reasearched the relationships between them and the recurrence of WHO ? meningiomas.(2)To provide some reference for the diagnosis and treatment of WHO ?meningiomas.Methods:A total of 84 definite cases of WHO ? meningiomas based on 2016 WHO classification system at the People`s hospital of Shanxi Province between January 2007 and December 2014 were selected.The clinicopathologic data,,imageology,morphological features and immunohistochemical of the patients were reviewed.The survival and recurrence were observed.Results:There were 40 males and 44 females in the 84 WHO ? meningiomas patients.The age range was from 24 years to 67 years with mean of 50.5 years,IQR [45.5-57.0].There were 44 patients having a headache,6 patients having visual deterioration and 8 patients having epileptic seizures.The tumor maximum diameter range was from 2.6 cm to10.7cm.The follow-up time of the 84 patients ranged from 24 months to 105 months with mean of 72 months,IQR[55,82].The RFS(recurrence-free survival)range was from24 months to 94 months with mean of 57 months,IQR[48-75].Following up data showed that recurrence was in 30 cases.Simple Kaplan-Meier analysis showed that the patientswith age older than 57 years,tumor maximum diameter large than 5cm,partial resection or Ki67 greater than 8 percent have greater rate of recurrence than the others(P <0.05).And the multivariate analysis showed that age(RR=0.238,95 % CI :0.065~0.868),tumor maximum diameter(RR=18.936,95%CI:2.112~169.773),Ki-67(RR=13.377,95%CI:2.293~78.045)and the extent of resection(RR=3.082,95%CI:1.013~8.137)were the independent risk factors affecting RFS.Conclusion:WHO ?meningiomas has higher recurrence tendency.Improving the operation skills and total resection rate are the main way to improve the prognosis of patients with WHO ? meningiomas.At the same time,the elder patients with sub-total resection,large tumor and high Ki-67 may have higher recurrence tendency.Giving early radiotherapy and shorting the review period may improve the prognosis.