Clinical Study On Perfusion Of Heart Injury Induced By Postoperative Radiotherapy Of Left Breast Cancer

Objective:The primary aim of this study was to investigate the value of ⁹⁹Tc^m-methoxyisobutylisonitrile?MIBI?single photon emission computed tomography?SPECT?gated myocardial perfusion imaging?GMPI?in the detection of radiation-induced heart disease?RIHD?after radiotherapy?RT?for breast cancer?BC?.The second aim was to analyse the correlation between cardiac toxicity and the dose-volume factors.Methods:We were followed up for patients with left breast cancer after radiotherapy,and eligible patients according to inclusion criteria and exclusion criteria.This patients performed ⁹⁹Tc^m-MIBI SPECT?the stress and the rest?GMPI on the same day.The results of the SPECT were quantitatively analysed with QGS/QPS software and read by two experienced nuclear medicine physicians.The correlation between the SPECT parameters and the RT dosimetric data was analysed.The dose-volume data of RT were analyzed to reflect the relationship between cardiac toxicity.Results:Ten patients with BC after RT were enrolled in the study.myocardial perfusion defects were observed in 3 of the 10 patients,are located in the apical segment,so single photon emission computed tomography gated myocardial perfusion imaging can be used for diagnosis of radiation-induced heart disease.The V39-V41 was significantly higher?p <0.05?in the patients with the new perfusion defects after RT than in the patients who did not exhibit these defects.Conclusion:Radiotherapy for BC induces cardiac damage.⁹⁹Tc^m-MIBI SPECT GMPI can detect the occurrence of cardiac impairment after RT.The percentage of the heart volume that receives a high dose is an important factor that is correlated with RIHD.