Clinical Analysis Of Antibiotics-induced Seizures In 38 Cases

Objective:The purpose of this paper is to provide more references for the relationship between antibiotic drugs and seizuresthrough collecting clinical data.And to analysis the further linkages between antibiotics and seizures.Method: Collecting the seizure/epilepsy cases in the 2nd affiliated hospital of CQMU from 2011-2016,totally 351 cases.And then we picked up 38 patients who may had antibiotics-induced seizures from it.We analyzed those cases from the patients' age,gender,basic diseases,drug kinds,methods for application,seizure kinds,etc.And gived out the statistics and summary.Result:Among the antibiotics-induced patients,males are more than female patients(male: female = 1.53:1),Greater than or equal to 60 years old(65.79%),with an average age of 63.2 years.The proportion of patients with cardiovascular and cerebrovascular diseases?disease of respiratory system ? hepatic and renal dysfunction ? a history of epilepsy are high.Most of the epilepsy patients keep taking VPA and LEV by themselves.Among those antibiotic drugs,piperacillin and its related drugs are frequently used,followed by fluoroquinolone drugs.Most of the patients are treated through intravenous drip.In the 38 patients,rate of patients taking on-steroidal drugs at the same time are the highest,reached 28.95%.Grand mal 25 cases,13 cases of limitations attack.The intervals of starting time to use antibiotics and the first seizure are ranging from 1 hour to 5 days.Among them 1-24 hours patients accounted for 73.68% of all cases of the disease.Conclusion:The elderly,patients with cardiovascular and cerebrovascular diseases?disease of respiratory system?hepatic and renal dysfunction? a history of epilepsy are easy to induce seizures,Quinolones,cephalosporins may induceseizures,Giving quinolones and theophylline/non-steroidal drugs at the same time may increase the incidence of epilepsy.Intravenous drip may also increase incidence of epilepsy.The statistical results are consistent with some articles and scholars point of views,For the sample size is small,the result is for reference only.Medical workers need to master the characteristics of epilepsy,prevent it,treat patients as soon as possible,in order to reduce patient's pain and sequelae.