HSF1 Expression In Cervical Cell Carcinoma And It's Association With Clinical Features And Prognosis

Objective:To assess the relationship of the Heat Shock Factor1(HSF1)expression with clinical pathologic characteristics and PFS in patients with cervical carcinoma.Methods:119 patients with stage IA-IIA cervical cancer who were diagnosed in our hospital during November 2009 and December 2013 and had undergone primary surgery were enrolled.Their clinical data and tissue blocks were collected.HSF1 expression was detected through immunohistochemistry and it's prognostic significance was analyzed retrospectively.Results:High HSFl expression was significantly related to the deep stromal invasion(P = 0.02).Similarly,higher HSF1 expression was also found in higher grade disease(P = 0.45),and those with lymph vascular involvement(P = 0.13)and lymph node metastasis(P = 0.80),however with no statistical significance.Although the expression of HSFl did not demonstrate prognostic significance(PFS,P = 0.33)in these 119 cases with early stage cervial cancer,the data of 320 cervial cancer patients inThe Cancer Genome Atlas Cancer Genome(TCGA)showed the association of increased HSFl expression with poor prognosis(P = 0.02).Conclusion:The increased HSF1 expression might reflect the invasiveness of cervical cancer,and it probablely predict the poor survival.