The Research Of Resting-state Functional Connectivity In Parkinson's Disease With Rem Sleep Behavior Disorder

Background: Rapid eye movement(REM)sleep behavior disorder(RBD)is a common non-motor symptom in Parkinson's disease(PD),and increases cognitive impairment risk.However,the pathogenesis of PD with RBD is unclear.Some studies showed that cognitive control impairment may be involved in the PD with RBD.The anterior cingulate cortex(ACC)is an important part of cognitive control,which might play a role in the pathophysiological mechanisms of PD with RBD.Methods: Fifteen patients with PD and no/less RBD(n PDR),15 patients with PD and RBD(PDR),and 17 matched healthy controls(HC)were recruited for the present study.All participants underwent resting-state functional MRI(RS-f MRI)scanning and clinical assessment.We conducted whole-brain resting-state functional connectivity(RS-FC)analysis to explore the functional activity of the bilateral ACC in the three study groups.Results: In current study,both PD groups showed abnormal ACC FC.Compared to the healthy controls,PD patients showed decreased ACC connectivity with the frontal lobe,parietal lobe,temporal lobe,occipital lobe and cingulate gyrus.However,the broader FC in PDR group,and PDR group also showed negative ACC FC with cerebellum and pons.Within the PD groups,the decrease ACC FC of PDR group in prefrontal cortex(PFC),pons,cerebellum and inferior temporal cortex(IT cortex).Moreover,PDR group also showed decrease FC in left ACC and supplementary motor area(SMA).Conclusions: Patients with PDR and n PDR showed abnormal ACC FC and the PDR group showed the broader FC than n PDR group,which may indicate that the more severe cognitive control impairment is involved in PDR.The abnormal cognitive control might play a role in the pathogenesis of PDR.