Dexmedetomidine Used For Intravenous Sedation Analgesia After Cesarean Section Of Clinical Observation

Objective: Through the dexmedetomidine hydrochloride injection is applied to elective intravenous sedation analgesia after cesarean section management efficacy and safety of blinded parallel,randomized,placebo controlled clinical observation,to provide reliable basis and suitable doses of dexmedetomidine for intravenous sedation analgesia after cesarean section.Method: Choice in our hospital,single child,BMI is less than 30 kg/m2,ages 18 to 45 years old,ASA ? ~ ? level,need underwent surgical primipara 40 cases of cesarean section and require postoperative intravenous analgesia,they were divided into C(control group)and D(test group)by the blind method,random and placebo.Two groups of patients with venous pathway and opening up,anesthesia monitoring right lateral position,the puncture needle reaches the subarachnoid cavity and is given to the radio of the proportion of ropivacation to 15 mg quickly after the epidur al catheter placement will be maternal recumbent and surgical bed 15 degrees to the left.No additional intravenous drugs and intravenous drugs are included in the operation.C group,in expelling the intravenous saline 20 ml after ten minutes,at least ten minutes to upload,Analgesia pump drugs : sufentanil 100 ug plus physiological saline total of 100 ml;D group,in expelling the dexmedetomidine according to the 0.5ug/kg(will right the dexmedetomidine for 20 ml solution with physiological saline)after ten minutes,at lesst ten minutes to upload,Analgesia pump drugs: sufentanil 100 ug,dexmedetomidine 300 ug plus physiological saline total of 100 ml.The PCA devices were identical in both groups: background dose1ml/h,bolus2ml/time,lock time 8min.Result: Observed two groups of patients with postoperative follow-up of incision pain and contractions pain VAS pain score less than four points,that two groups of patients can tolerate postoperative pain and do not need other auxiliary analgesia.Considering the VAS scores at postoperative 4h,8h,24 h,48h,and the PCA number and PCA sufentanil consumption at any given time: Group C exceeded Group D.And the differences are statistically significant(p<0.05),it is suggested that dexmedetomidine can reduce the dosage of the schuffinoni and strengthen the postoperative analgesic effect.But the OAA/S stores at the end of the surgery immediately,postoperative 4 h,8 h,24 h,48 h,only at the end of the surgery immediately and postoperative 4 h,Group C exceeded Group D,and there was no statistically significant difference in other,on the one hand dexmedetomidine can let patients keep calm,greatly improve the safety and comfort during the procedure,on the other hand,can reduce the incidence of postoperative irritability,not interfere with the maternal care of newborn or affect the establishment of the breast,provide a good recovery.It is different for each group about adverse reaction rates,Group C exceeded Group D.And D Group have a higher rate of statically significance than Group C.Lactation time two groups of patients were 53-55 hours,no statistical difference,combined with the right holder microphones on the characteristics of the pharmacokinetic half-life 2 hours,48 hours can be concluded that basic stop using PCA device can guarantee drug concentration in breast milk is extremely trace.Conclusion:Follow-up observations were found,dexmedetomidine used for intravenous sedation analgesia after cesarean section is reliable,not only can reduce the dosage of the schuffinanil,but also strengthen the effect of the postoperative analgesia,and maintain the stability of the patient's hemodynamic,but also shaving certain calming effect,the light can wake up and help relieve the patient's anxiety and mood.at the same to reduce the incidence of maternal nauses and vomiting,improving maternal satisfaction.So in clinical applications,the use of drugs is strictly controlled,combined with drugs in order to make the best of the both worlds,and can be applied in clinic safely.