Genetic Epidemiological Investigation On Gaomi City Primary Convulsive Epilepsy

Objective: To evaluate the primary convulsive epilepsy genetic effect.Methods: Cluster epidemiological investigation methods,to meet the primary convulsive epilepsy criteria for the diagnosis of 536 cases of the proband families come to survey.To find a positive family history of patients with face detection rate is 100%.This study was conducted in Gaomi City convulsive epilepsy epidemiological investigation based on the control group,no more,and Gaomi City to the convulsive epilepsy group epidemiology prevalence data for the control.Results: The results were investigated the proband one or two relatives of 16489 persons.8cases were found in patients with epilepsy probands,relatives prevalence rate of 0.049%.Gaomi City convulsive epilepsy epidemiological data outcome groups in the prevalence rate is 0.063%.There was no statistical significance(P = 0.5631).According to the Falconer threshold model theory,the heritability estimates,first-degree relatives of h2 = 24.6%,not more than 60%,does not conform to the dominant,recessive inheritance,sex-linked inheritance and polygenes inheritance model,two relatives of B-0.157,and genetically unrelated.Conclusions: The genetic factors in primary convulsive epilepsy etiology is not important.Considering its cause may be associated with childhood neurodevelopmental abnormalities.