A Comparative Study Of CTP On Microvascular Permeability In Acute Stage Of Cerebral Infarction At Different Altitude Areas

Objective: To investigate the changes of microvascular permeability in acute stage of cerebral infarction at different altitudes by using CTP,and analysis the patients’ features of hemorrhagic transformation with cerebral infarction and the relationship with PS value in the hypoxia environment at high altitude,in order to facilitate early intervention in patients with acute cerebral infarction and to avoid the occurrence of HT.Methods: To collect 32 patients with acute cerebral infarction at middle altitude,32 cases high altitude,all patients had routine head CT scan and CTP scan and postprocessing the datas to get MTT,PS values and its perfusion image information.Results:1.The ratio of the area with increased PS value to the area with prolonged MTT value in the high altitude group(0.54±0.13)is higher than the middle altitude group(0.42±0.27),the difference was statistically significant(P < 0.05);2.The PS values in high altitude group(4.53±1.99 ml/100g/min)is higher than the middle altitude group(3.00±1.54ml/100g/min),the difference was statistically significant(P < 0.05);3.Fourteen cases of HT occurred in AIS patients of the high altitude group for review,and when SPS/SMTT>0.56,the specificity of the occurrence of HT is 83.3% and the susceptibility is 71.4%;when PS value>4.67ml/100g/min,the specificity of the occurrence of HT is 77.8% and the susceptibility is 85.7%.Nine cases of HT occurred in AIS patients of the middle altitude group for review,and when SPS/SMTT>0.43,the specificity of the occurrence of HT is 65.2% and the susceptibility is 88.9%;when PS value>3.08ml/100g/min,the specificity of the occurrence of HT is 73.9% and the susceptibility is 88.9%.Conclusion: The PS value of cerebral infarction in acute cerebral infarction and the ratio of the area with increased PS value to the area with cerebral infarction at different altitudes was different,which reflected the different degree of microvascular permeability and blood brain barrier after cerebral infarction,and the predictive value of PS value to HT is higher than that of SPS/SMTT.Patients with acute cerebral infarction in high altitude areas may be more prone to hemorrhagic transformation.