The Effect Of Vitamin D To Hypertension And Metabolism Of Glucose And Lipid In Patients With Osteoporosis

ObjectivesOur study is mainly to discuss the role of vitamin D in osteoporosis combined with hypertension or type 2 diabetes or dyslipidemia through detecting the level of serum 25-hydroxyvitamin D3 in osteoporosis patients with or without hypertension or type 2 diabetes or dyslipidemia.Methods1.Collecting information of participants who were first diagnosis of osteoporosis from Fujian Provincial Hospital during January 2014 to October 2016.Participants were grouped into three couple:(1)osteoporosis with hypertension(OH group)and osteoporosis without hypertension(OS1 group),(2)osteoporosis with type 2 diabetes(OD group)and osteoporosis without type 2 diabetes(OS2 group),(3)osteoporosis with dyslipidemia(OL group)and osteoporosis without dyslipidemia(OS3 group),(4)enough vitamin D group(VDE group)and vitamin D deficiency group(VDD group).2.Record all clinical data and laboratory results of all participants who met inclusion and exclusion criteria requirements.3.Statistical processing: use SPSS 19.0 statistics software process the data,comparing the grouping variable difference,select statistically difference variables,and using the Spearman rank correlation analysis the correlation between the variables.And if P < 0.05,then we think the difference was statistically significant.Results1.Compared with OS1 group,25-hydroxyvitamin D level of OH group(16.56±7.86)is lower than the OS1 group(22.51±8.56)(P < 0.05);Compared with OS2 group,25-hydroxyvitamin D level of OD group(17.73±8.50)is less than OS2 group(24.13±7.30)(P < 0.05);Compared with OS3 group,25-hydroxyvitamin D level of OL group(17.91 ± 9.01)and OS3 group(21.64 ± 7.12)were no statistically significant difference(P = 0.069 > 0.05).2.Compare with VDE group,the age of VDD group(68.00±9.35)higher than the VDE groups(61.03±11.75)(P<0.05);the height of VDD group(155.45±6.57)is lower than the VDE group(158.47±5.76)(P<0.05);the systolic blood pressure of VDD group(143.80±19.56)higher than the VDE groups(131.29±18.68)(P<0.05);the total triglyceride of VDD group(2.23±2.06)higher than the VDE group(1.21±0.97)(P< 0.05);the HDL-c of VDD group(1.17±0.35)is lower than the VDE group(1.44± 0.42)(P<0.05);the fasting blood glucose of VDD group(9.07±3.50)higher than the VDE group(6.94±3.38)(P<0.05).3.After controlling confounding factors,Spearman rank correlation analysis: 25-hydroxyvitamin D was negatively correlated with systolic blood pressure(r =-0.218,P < 0.05);negatively correlated with triglyceride(r =-0.288,P < 0.05);positively related with HDL-c(r=0.269,P < 0.05);not statistically significant correlated with fasting plasma glucose(r =-0.204,P = 0.204).Conclusions1.Low level of vitamin D is a risk factor for osteoporosis complicated with hypertension.2.Low level of vitamin D may be associated with osteoporosis complicated with type 2 diabetes.3.Vitamin D level associated with lipid metabolism in patients with osteoporosis.Vitamin D level was negatively correlated with triglyceride,and positively correlated with high-density lipoprotein cholesterol level.