The Effect Of CPAP Treatment On Venous Lactate And Arterial Blood Gas Among Obstructive Sleep Apnea Syndrome Patients

Purpose: Obstructive sleep apnea hypopnea syndrome(OSAHS)is a common sleep disorder.The aim of this observational study was to determine the risk factor of serum lactate and PH in OSAHS patients,and investigate the influence of continuous positive airway pressure(CPAP)on arterial blood gas and venous lactate,markers of tissue hypoxia,among OSAHS patients.Materials and methods: A total of 109 consecutive patients who underwent standard polysomnography and diagnosed OSAHS between September 2015 to May 2016 were enrolled.All individuals were treated with CPAP for one night.The biological profile measurements and demographic data were collected from all patients.Venous lactate and arterial blood gas were gathered from all fasting subjects in the morning at the end of polysomnography,and the next morning after CPAP treatment.Results: Pearson's correlation shown that neck circumference and the polysomnographic parameters,including AHI,ODI and TS90%,positively correlated with lactate(r=0.214?0.213?0.210 and 0.461,respectively;all p<0.05),while age and mean Sp O2 correlated negatively with lactate(all p<0.05).Significantly positive associations were found between age,neck circumference and PH(r=0.378 and 0.214;p=0.000,0.049,respectively),furthermore,negative correlation was found between ODI and PH(r=-0.215,p=0.025).Finally,after adjusting for confounding factors,TS90% was the major contributing predictor for elevated lactate(p<0.05),and age was a predictor for an increase in PH(p<0.05).In addition,Of the 109 selected subjects,average lactate levels was 2.23±0.59 mmol/L,and mean PH,Pa O2,Pa CO2 were 7.380±0.23,88.14±17.83 mm Hg,38.70±4.28 mm Hg,respectively.Compared to baseline,lactic acid significantly decreased(2.10±0.50 mmol/L,p=0.03),while PH increased(7.388±0.27,p<0.05)after CPAP treatment.Conclusions: The results indicated that TS90% was a risk factor for elevated lactate,and age was independently associated with PH.Furthermore,CPAP treatment could reduce serum lactate and increase PH in OSAHS patients,and might alleviate acid-base disorders in OSAHS.