Changes And Clinical Significance Of Serum Homocysteine Levels In Children With Nephrotic Syndrome

Objective:To compare the changes of serum homocysteine levels in children with nephrotic syndrome(NS)and to observe the correlation between plasma homocysteine levels and plasma albumin,and to analyze its causes and clinical significance.Methods:Collected from January 2016 to February 2017 in The first hospital of Shanxi Medical University and Shanxi Children's Hospital for the first time diagnosed with NS in children with 30 cases,while 30 cases with non-nephrotic syndrome.In the morning fasting 4ml of blood,and then the serum homocysteine levels was detected by ELISA,the serum albumin levels was detected in children with NS.SPSS 18.0 was used to analyze the plasma homocysteine levels between NS and control and the relationship between Hcy and albumin in childern with NS.Finally combined with clinical,analytical data meaning.Result:1.The serum Hcy concentration in children with NS was 11.310 ± 3.568?mol / L and 7.373 ± 2.444?mol / L in the control group.The data of the two groups were analyzed by analysis of covariance(P<0.001),the difference was statistically significant;2.There was a positive correlation between plasma Hcy concentration and albumin in children with nephrotic syndrome.Conclusion:1.HHcy can not only lead to glomerular sclerosis,but also can promote thrombosis,but the study found that there are different levels of HHcy in children with NS,thus reducing the concentration of Hcy may delay the kidney damage,reduce the risk of NS in children with renal vein thrombosis.2.The majority of Hcy in plasma is the binding of albumin and the serum Hcy is positively correlated with the concentration of albumin,so the low frequency of proteinuria caused by urinary protein excretion may influence the plasma Hcy concentration.