Different Androgen Deprivation Therapy For Advanced Prostate Cancer Study On The Relationship Between The Risk Of Secondary Diabetes And Impaired Glucose Tolerance

Objective:To investigate the relationship between two different ways of intermittent androgen deprivation therapy(IADT)and continuous androgen deprivation therapy(CADT)for advanced prostate cancer(PCa)and the risk of diabetes mellitus(DM)and impaired glucose tolerance(IGT).Methods:A retrospective case-control study was conducted among PCa patients with ADT in our hospital from January 2013 to December 2015.By monitoring fasting patients blood glucose,2 hour postprandial blood glucose and oral glucose tolerance test combined with clinical symptoms in patients with IADT and CADT,DM and IGT of the risk caused by statistical analysis,and analyze the relationship between group Body mass index(BMI),hypertension,smoking,alcohol drinking and secondary DM and IGT.Results:IADT group of 53 cases,accounting for 46.5%,with an average age of(69.1±4.3)years;CADT group of 61 cases,accounting for 53.5%,with an average age of(70.2±5.7)years,two groups had no significant difference in clinical characteristics(all p>0.05);IADT group of BMI,blood pressure,smoking,drinking alcohol on the occurrence of DM,IGT had no significant effect(all p > 0.05),CADT group of BMI,hypertension,smoking,drinking alcohol on the occurrence of DM,IGT had no significant effect(all p > 0.05);IADT group compared with CADT group,the incidence of DM caused no significant difference(P=0.643);but due to the occurrence of IGT was statistically significant(P= 0.029).Conclusion:IADT compared with CADT,although there is no difference on cause secondary DM,but IADT reduced sugar metabolic disorder,diabetes stem in the early state,to a certain extent,reduce the secondary the happening of DM,IADT CADT relatively high security.