The Effect Of Ketorolac Preemptive Analgesic On The Children' Laparoscopic Surgery Postoperative Stress Response

Objective: The study is about the effect of ketorolac preemptive analgesic on the children' laparoscopic surgery postoperative stress response,TXA-2 and GMP-140.Methods: The study had two groups: observation and control groups.The ketorolac was used in observation group for preemptive analgesic and no preemptive analgesic for control group.Sixty 2~12 year old infants were divided into the two groups randomly.The postoperative stress response,TXA2 and GMP140 were compared.Results:(1)The cortisol,epinephrine,norepinephrine levels of observation group was significantly lower than control at 0.5h and 6h(P<0.05).However,there was no significantly difference at 24h(P>0.5).(2)The TXA-2 and GMP-140 level of observation group was significantly lower than control at 0.5h(P<0.5).However,there was no significantly difference at 6h and 24h(P>0.05).(3)The side effect ratio of observation group was lower than control.Conclusion: the postoperative stress response,platelet activation can be inhibited by the application of ketorolac preemptive analgesic on infants' hypogastrium operation.At the same time,the side effect ratio was also significantly lower too.