Clinical Research On Corneal Endothelial Changes In Patients With Metabolic Syndrome

Objective: This study evaluated the differences of corneal endothelial morphology in metabolic syndrome(MS)and its components compared with agematched,healthy control subjects.Methods: A population-based sample of 124 inpatients(n=229eyes)was used for this analysis,which were collected from March 2015 to October 2015 during the Second Affiliated Hospital of Chongqing Medical University,Department of Endocrinology and Ohthalmology.Abdominal circumference,blood lipids,blood glucose,blood pressure of all patients were detected,according to detection results,they were divided into diabetic group(n=18eyes),hypertension group(n=26 eyes),dyslipidemia group(n=57 eyes),metabolic syndrome group(n=78 eyes)and control group(n=50 eyes).All eyes were performed on noncontact specular microscopy.SPSS20.0 statistical software was used to analyze datas.Method for normal distribution test is the one sample Kolmogorov-Smirnov test,the three variables of corneal endothelial cells of the average density(ECD),coefficient of variation in cell(CV)andpercentage of hexagonal cells(H%),approximated a normal distribution after the examination,through Levene test examing homogeneity of variance between the groups.Datas between different groups were analyzed using variance,if there were significant differences,differences in measurement data were compared with LSD analysis of variance,P<0.5was considered significant.Results:1.The diabetic subjects had less cell density of the corneal endothelium and had a lower percentage of hexagonal cells than did the controls(P<0.05).2.The coefficient of variation of cell size was higher for hypertension subjects than for the controls(P<0.05),the percentage of hexagonal cells was lower for hypertension subjects(P<0.05).3.Significant differences in corneal endothelial parameters,including the coefficient of variation for cell size and percentage of hexagonal cells,were observed between the dyslipidemia groups and the controls,the former having a lower percentage of hexagonal cells and a higher coefficient of variance of cell size(P<0.05).4.There were significant differences in the coefficient of variation of cell size(P < 0.01)and percentage of hexagonal cells(P < 0.01)between MS groups and the controls.5.There were not statistical significances in the age and sex of thepatients among five groups,and abdominal circumference of four groups except for MS group(P>0.05).Conclusion: Those patients with any component of metabolic abnormality have more corneal morphological abnormalities,especially with the metabolic syndrome,compared with the controls.