The Study About Clinical Features Of Early Parkinson’s Disease Without Constipation

ObjectiveConstipation is among the most frequently delineated nonmotor symptoms(NMS)with a high occurrence in Parkinson’s disease(PD)and can predate the onset of motor symptoms by many years as well as presenting with the disease progression.However,there are some PD patients presenting without constipation during the early stage of disease.The purpose of our study was to investigate whether this group of patients had different clinical features compared to constipated patients.MethodWe conducted a retrospective monocenter chart view of 105 PD patients consecutively visiting the first affiliated university of Chongqing medical university during 1st,Jan,2013-30 th,Dec,2015.Subjects were administered motor and nonmotor questionnaire as well as Constipation associated examinations.Then,we explored the distinctive features of nonconstipated contrasted to constipated PD by using univariate,multiply regression analysis and correlation analysis.ResultsNonconstipated PD tended to have fewer motor deficits and NMSloads,as well as a lower Hoehn and Yahr(H&Y)stage and prevalence of NMS compared to constipated ones.Binary logistic regression suggested that nonconstipated patients still showed prominently fewer motor deficits and NMSloads than constipated patients after controlling the interference factors;Nonconstipated patients mainly presented as tremor-dominant(TD)compared to constipated patients,who had a higher occurrence of posture instability and gait difficulty(PIGD);Correlation analysis found a discord between NMSloads and severity of the disease based on H&Y stage and motor scores in nonconstipated PD.ConclusionsThese results suggest that PD without constipation may represent a unique clinical phenotype,which may be more benign than PD with constipation.