Systemic Lupus Erythematosus-associated Collapsing Glomerulopathy

Historically,collapsing glomerulopathy(CG)was konwn as a variant of focal segmental glomerular sclerosis(FSGS)and was nearly always related to human immunodeficiency virus(HIV).However,CG has now been recognized in association with numerous other conditions,such as systemic lupus erythematosus(SLE).SLE-associated CG is a distinct clinicopathologic entity in patients with SLE who were not associated with HIV,parvovirus B19,hepatitis C virus,drugs or the other primary causes of CG,and is characterized by significant proteinuria,poor response to immunosuppressive therapy,and rapid progression to renal failure.In this article,we will review recent progress on SLE-associated CG.