An Analysis Of The Related Influencing Factors For Initial Poor Graft Function After Liver Transplantation

Objective: To analyze the related influencing factors for initial poor graft function(IPGF)after liver transplantation(LT).Clinical Data and Methods:107 cases who underwent liver transplantation from March in 2014 to November in 2015 were selected randomly.The group of IPGF is confirmed if ALT and/or AST are above 1500IU/L,while non-IPGF below 1500IU/L within 72 h after LT.The donor related influencing factors includes age,source,warm ischemic time,cold preservation time,liver biopsy at the end of cold ischemia and if there is a Supplementary perfusion at the end of cold ischemia.The recipient related influencing factors includes gender,age,primary liver diseases,Child's classification,MELD score,ECOG score.The related factors of the operation includes operative approach,total operative time,bleeding during the operation and infusion amount,anhepatic time,rewarm ischemic time(RWIT),ascites volume and complication,if there is the portal vein thrombosis(PVT),if there is the splenic artery ligation(SAL).The postoperative related influencing factors includes intubation time and ICU monitoring time.Results: There are 31 cases(28.97%)in IPGF group and 67 cases(71.03%)in non-IPGF group.The result of ALT and/or AST are significantly higher in IPGF group than in non-IPGF group(P<0.05).The recovery time of liver function is significantly longer in IPGF group(20.50�5.28d)than in non-IPGF group(13.20�5.50d)(P < 0.01).The donor warm ischemic time is significantly longer in IPGF group(4.34�2.25min)than in non-IPGF group(2.18�1.90min)(P<0.05).The cold preservation time were significantly longer in IPGF group(9.73�1.19h)than in non-IPGF group(9.24�0.99h)(P<0.05).There was a marked difference between the 2 groups in spite of higher values in Child C recipients' ratio.The rest of related influencing factors had no marked differences between the 2 groups.Conclusions: Longer donor warm ischemic time and cold preservation time and Child C recipients' ration are important risks factors for IPGF.