Analysis Of Factors Influencing The Ultra-short-course Chemotherapy After Operation Of Spinal Tuberculosis

Objective To investigate the factors influencing the ultra-short-course chemotherapy after operation of spinal tuberculosis.Methods In total,211 cases of spinal tuberculosis who were treated by surgery in January 2004 to December 2013 in the Department of Spine Orthopedics of General Hospital of Ningxia Medical University,were retrospectively reviewed.Among them,120 patients were treated with ultra-short-course chemotherapy,male 59 cases,female 61 cases,with an average age of 37.91±16.71 years;the other was non ultra-short-course chemotherapy in 91 cases,male 47 cases,female 44 cases,with an average age of 43.67±16.56 years.The clinical data of two groups of patients with preoperative and perioperative were collected,including primary or recurrent,the age,whether the patients had other diseases before operation,whether they had active tuberculosis in other sites,whether anemia,segment involvement,abscess,surgical staging,material of graft,thorough focus debridement,mode of grafting,drug resistance and so on 12 aspects.Univariate Logistic regression analysis was used to selecte variables,then multivariate Logistic regression analysis was statistically significant among the variables,suggesting the factors that may affect ultra-short course of chemotherapy in spinal tuberculosis after surgery.Results 120 cases of ultra-short-course chemotherapy were followed up for 38 to 154months(average 90.11±30.81 months),the duration of chemotherapy was from 3 to 6months(average 4.65±0.98 months).91 cases of non ultra-short-course chemotherapy were followed up for 45 to 153 months(average 89.73±28.08 months),the duration of chemotherapy was from 6.5 to 34 months(average 11.32±5.30 months).Univariate and multivariate Logisticregression analysis results show:there was a significant correlation between thorough focus debridement,mode of grafting,segment involvement and the ultra-short course course chemotherapy after spinal tuberculosis(P<0.05).Conclusion Thorough focus debridement and supporting graft are the favorable factors for the ultra-short course chemotherapy;Lesion involving multiple segments is an unfavorable factor for the ultra-short course chemotherapy.