Clinical Analysis Of Serum Cystatin C Expression Level And Its Structure In Acute Cerebral Ischemia Patients

Objective: To investigate the changes of serum Cys C expression levels and its structure(monomer / oligomer)in acute cerebral ischemic patients.To analyze the expression level of serum Cys C in different group(mild and moderate)of acute cerebral ischemia.Methods: A total of 32 patients with acute cerebral infarction were admitted to the Department of Neurology and Stroke of General Hospital of Ningxia Medical University from May 1,2016 to August 31,2016.The NIHSS score was divided into two groups: mild,and moderate to NIHSS score.A total of 26 healthy people were selected as the control group.The clinical data of the two groups were gathered and blood samples were collected respectively after 8 hours of fasting.The expression level of serum Cys C was determined by ELISA and the expression of Cys C was determined by western blotting.Results: There were no significant differences in clinical data such as gender,age,blood pressure,blood glucose,smoking history and drinking history in acute cerebral ischemia group(P> 0.05).The serum Cys(0.867 ± 0.099)mg / L],the difference between the two groups was statistically significant(t = 3.056,P = 0.003);acute cerebral ischemia group The serum Cys C oligomer(87.5%)was significantly higher in the patients than in the control group(19.2%),and the difference was statistically significant(X2 = 27.261,P<0.001).(P <0.05).Conclusion: The level of serum Cys C expression in patients with acute cerebral ischemia is higher than that in patients with acute cerebral ischemia.The level of serum Cys C expression in patients with acute cerebral ischemia is mainly elevated;There is noobvious relationship between the severity of acute cerebral ischemia and the expression of Cys C.